Ross Patrick Byrne

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

The paper identifies seven sex-dependent differentially methylated positions in ALS blood samples, suggesting sex-specific biological mechanisms in the disease.

Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traits

The paper identifies shared and distinct genetic loci linking ALS, sFTD, and cognitive traits using genome-wide association data.

Rare neurological and neurodevelopmental variants in ALS link to onset, survival and family history

This study identifies rare neurological and neurodevelopmental variants in ALS patients, showing associations with onset, survival, and family history patterns across two cohorts.

A genetic perspective on the recent demographic history of Ireland and Britain

The paper uses genetic data to infer demographic history in Ireland and Britain, finding population bottlenecks, migration patterns, and surname enrichments in specific communities.

Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis

The paper identifies sex-associated DNA methylation differences in ALS using a large-scale epigenome-wide association study and links them to survival outcomes.

Sex-specific risk loci and modified MEF2C expression in ALS

The paper identifies sex-specific risk loci for ALS, including MEF2C, which is upregulated in female ALS motor neurons, and an X-chromosome locus at IL1RAPL2.

Dutch population structure across space, time and GWAS design

The paper analyzes Dutch population structure using genome-wide data, identifying haplotypic clusters and showing that fine-grained haplotypic covariates reduce GWAS confounding.

Insular Celtic population structure and genomic footprints of migration

This paper uses haplotype-based methods to reveal genetic structure in Ireland, showing regional diversity and historical migrations, with implications for genetic association studies.