Author

Lorena Leonardelli

The Microsoft Research - University of Trento Centre for Computational and Systems BiologyORCID 0009-0004-0345-1250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Elio CampanileiD· 1 shared Elisa PettinàiD· 1 shared Luca MarchettiiD· 1 shared Stefano GiampiccoloiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperPharmacology & Toxicology

Elio CampanileORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyMolecular Therapy — Nucleic AcidsPeer-reviewedJul 8, 2026

Physiologically Based Pharmacokinetic Modeling of mRNA-Encoded Therapeutics: A Multiscale Framework for LNP and Antibody Trafficking in Mice

Elio Campanile, Elisa Pettinà, Stefano Giampiccolo…·Luca Marchetti

The paper develops a multiscale pharmacokinetic model integrating mRNA trafficking and antibody disposition in mice, validated with experimental data to predict biodistribution and optimize dosing.

DOI 10.1016/j.omtn.2026.103002

mousebulk RNA-seq

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