Luca Marchetti

Physiologically Based Pharmacokinetic Modeling of mRNA-Encoded Therapeutics: A Multiscale Framework for LNP and Antibody Trafficking in Mice

The paper develops a multiscale pharmacokinetic model integrating mRNA trafficking and antibody disposition in mice, validated with experimental data to predict biodistribution and optimize dosing.

A novel approach to quantify out-of-distribution uncertainty in Neural and Universal Differential Equations

This paper introduces a novel ensemble method for NODEs and UDEs to improve out-of-distribution uncertainty quantification in dynamical systems.

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments.

stormTB provides a web-based mPBPK model for simulating anti-TB drug treatments in mice, enabling pharmacokinetic comparisons and supporting 11 drugs.

Robust parameter estimation and identifiability analysis with Hybrid Neural Ordinary Differential Equations in Computational Biology

The paper introduces a workflow for estimating model parameters and assessing identifiability in hybrid models with partial system knowledge using neural ordinary differential equations.

Exploring alternative quorum sensing model structures and quorum quenching strategies

This study compares two synthetic quorum sensing circuit architectures and evaluates three QS inhibition strategies to understand their steady-state behavior and parameter thresholds for effective suppression.