Author

Brigette Kobs

Harvard UniversityORCID 0009-0004-0467-0893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:spatial transcriptomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Eliezer M. Van AlleniD· 2 shared Peter Karl SorgeriD· 2 shared Zoltan MaligaiD· 2 shared Aishwarya AtmakuriiD· 1 shared Akash PatnaikiD· 1 shared Ali AmiryousefiiD· 1 shared Andreanne GagneiD· 1 shared Brian William LabadieiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Eliezer M. Van AllenORCID

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2 papers

Recent·Most cited

Immunogenic tumor mass dormancy as a driver of persistent residual lesions in immunotherapy-treated melanoma

Yingxiao Shi, Zoltan Maliga, Tuulia Vallius, Shishir Mani Pant, Roxanne J. Pelletier, Brigette Kobs, Priyanka Solanky, Yiwen He, Eliezer M. Van Allen, Sandro Santagata, Patrick Alexander Ott, Christine Guo Lian, Elizabeth Iannotti Buchbinder, David Liu, Peter Karl Sorger

This study shows that immunogenic tumor mass dormancy, not cell-level quiescence, persists in residual melanoma lesions after immunotherapy, with active tumor cells and immune interactions.

bioRxiv · Jun 27, 2026 · PreprintCancer Biology

Spatial statistics for identifying and scoring immune clusters in high-plex profiles of primary prostate cancer

Ali Amiryousefi, Jeremiah A. Wala, Jia‐Ren Lin, Brian William Labadie, Aishwarya Atmakuri, Zoltan Maliga, Eamon Toye, Kiranj Kishor Chaudagar, Madeleine S. Torcasso, Shannon Coy, Giuseppe Nicolò Fanelli, Brigette Kobs, Fabio Socciarelli, Andreanne Gagne, Eliezer M. Van Allen, , Peter Karl Sorger

The paper introduces statistical tools to analyze immune cluster patterns in prostate cancer and finds high-grade tumors show more immune infiltration and active immune features.

bioRxiv · Sep 21, 2025 · PreprintCancer Biology