NeuroscienceNeurobiology of DiseasePeer-reviewed
Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2+/- mice
Mackenzie Smith, Grace E. Dodis, Amanda M. Vanderplow…·Rocco G. Gogliotti
This study shows that M1 receptor potentiation reduces apnea severity in Mecp2+/- mice by normalizing brainstem hyperactivity and altering neuronal activation patterns.