Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2+/- mice
Mackenzie Smith, Grace E. Dodis, Amanda M. Vanderplow, Sonia Gonzalez, Yewon Rhee, Karie Elizabeth Scrogin, Rocco G. Gogliotti
This study shows that M1 receptor potentiation reduces apnea severity in Mecp2+/- mice by normalizing brainstem hyperactivity and altering neuronal activation patterns.
Neurobiology of Disease · Feb 26, 2025Peer-reviewedNeuroscience