Author

Sih-Sian Wu

Nara Institute of Science and TechnologyORCID 0009-0004-1066-3403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Hideki ShigematsuiD· 2 shared Hidetaka KohgaiD· 2 shared Hiroyuki TanakaiD· 2 shared Kaito HosodaiD· 2 shared Ryoji MiyazakiiD· 2 shared Tomoya TsukazakiiD· 2 shared Kunihito Yoshikaie· 1 shared Min Fey ChekiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMolecular Biology

Hideki ShigematsuORCID

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2 papers

Recent·Most cited

Molecular BiologyPLoS BiologyPeer-reviewedOct 27, 2026

Structural basis for MurJ inhibition by phage lysis protein SglPP7 suggesting convergence

Kaito Hosoda, Hidetaka Kohga, Sih-Sian Wu…·Tomoya Tsukazaki

The paper determines the cryo-EM structure of the MurJ-SglPP7 complex, revealing how SglPP7 inhibits MurJ and suggesting convergent evolution among phage lysis proteins.

DOI 10.1371/journal.pbio.3004039

E. coliexperimental assay

𝕏 PostBluesky

Molecular BiologyScience AdvancesPeer-reviewedOct 8, 2025

Phage lysis protein LysM acts as a wedge to block MurJ conformational changes

Hidetaka Kohga, Napathip Lertpreedakorn, Ryoji Miyazaki…·Tomoya Tsukazaki

The paper reveals how phage lysis protein LysM blocks MurJ conformational changes by acting as a wedge, providing a structural basis for designing antimicrobial agents targeting MurJ.

4 citations

E. coliprotein structure

𝕏 PostBluesky