Author

Varpu Johanna Mäkinen

University of TurkuORCID 0009-0004-1916-3528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Annukka Pietikäinen· 1 shared Annukka PietikäineniD· 1 shared Jukka Alinikula· 1 shared Jukka AlinikulaiD· 1 shared Jukka Hytönen· 1 shared Jukka HytöneniD· 1 shared Kirsi Gröndahl‐Yli‐HannukselaiD· 1 shared Marko Salmi· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Annukka Pietikäinen

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 3, 2026

CTLA-4 checkpoint signalling modulates germinal centre dynamics and antibody avidity during Borrelia burgdorferi infection in mice.

Varpu Johanna Mäkinen, Jukka Alinikula, Ruth Fair-Mäkelä…·Jukka Hytönen

This study shows that CTLA-4 signaling impairs antibody quality during Borrelia infection by affecting germinal center dynamics and T cell responses in mice.

DOI 10.64898/2026.10.30.763258

mousescRNA-seq

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Molecular BiologybioRxivPreprintNov 29, 2023

Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice

Varpu Rinne, Kirsi Gröndahl‐Yli‐Hannuksela, Ruth Fair-Mäkelä…·Jukka Hytönen

This study uses single-cell RNA sequencing to analyze the early immune response in lymph nodes of Borrelia burgdorferi-infected mice, identifying B cell proliferation, immunoglobulin class switching, and changes in gene expression associated with extrafollicular immunity.

DOI 10.1101/2023.11.29.569164

mousescRNA-seq

𝕏 PostBluesky