Prenatal liver is resistant to low glucose-induced inhibition of mTORC1
Chen-Jie Zhang, Chuanjin Yu, Yi Cheng, Jiexue Pan, Long‐Yun Ye, Yunhui Tang, Xueyun Qin, Zhong‐Liang Lin, Chen‐Song Zhang, Guolian Ding, Sheng‐Cai Lin, Hefeng Huang
The paper shows that prenatal liver mTORC1 remains active under low glucose, unlike adult liver, due to TRPV4 acetylation preventing FBP-mediated inactivation.
bioRxiv · Jul 21, 2025 · PreprintBiochemistry