Sheng‐Cai Lin

This study shows glucose directly binds to glucokinase (GK) to trigger GLP-1 secretion in intestinal L cells, independent of ATP levels, and identifies GK and KATP as key players in this process.

This study shows that aldometanib activates AMPK to enhance CD8+ T cell infiltration and control hepatocellular carcinoma growth in immune-competent mice.

The paper shows that prenatal liver mTORC1 remains active under low glucose, unlike adult liver, due to TRPV4 acetylation preventing FBP-mediated inactivation.

This study identifies a mechanism where AMPK and cGAS-STING signaling synergize through glucose and dsDNA sensing to enhance antitumor immunity in melanoma and colorectal cancer.

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.