Author

Ryan Jaehne

Caris Life Sciences (United States)ORCID 0009-0004-4135-2325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrian V. LeeiD· 1 shared Alexander Chih-Chieh ChangiD· 1 shared Daniel D. BrowniD· 1 shared Danielle Tseng· 1 shared Guilherme Nader MartaiD· 1 shared Hunter WaltermireiD· 1 shared Jagmohan HoodaiD· 1 shared Jie Bin Liu· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adrian V. LeeORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintJun 19, 2026

Dual HER2/HER3 Targeting with Antibody-Drug Conjugates Reveals a Novel Therapeutic Strategy for HER2-Mutant Lobular Breast Cancer

Jie Bin Liu, Ye Cao, Alexander Chih-Chieh Chang…·Steffi Oesterreich

This study shows HER2 mutations drive HER2/HER3 hyperactivation in ILC, making it sensitive to HER2/HER3-targeting ADCs, and highlights the synergy between T-DXd and P-DXd.

DOI 10.64898/2026.06.18.733194

humanproteomics

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