Dual HER2/HER3 Targeting with Antibody-Drug Conjugates Reveals a Novel Therapeutic Strategy for HER2-Mutant Lobular Breast Cancer
Jie Bin Liu, Ye Cao, Alexander Chih-Chieh Chang, Ryan Jaehne, Daniel D. Brown, Hunter Waltermire, Danielle Tseng, Rinath M. Jeselsohn, Guilherme Nader Marta, Jagmohan Hooda, Julia Foldi, Marija Balić, Adrian V. Lee, Steffi Oesterreich
This study shows HER2 mutations drive HER2/HER3 hyperactivation in ILC, making it sensitive to HER2/HER3-targeting ADCs, and highlights the synergy between T-DXd and P-DXd.
bioRxiv · Jun 19, 2026 · PreprintCancer Biology