Phosphoinositide turnover through PLCγ regulates Draper-dependent engulfment in glia
Freya Storer, E. A. MacKinnon, Hannah J Lucas-Clarke, Daniel C. Maddison, Leonardo Amadio, Thejaswini Susobhanan, Bilal R. Malik, Owen M. Peters, Gaynor Ann Smith
This study shows that PLCγ-dependent phosphoinositide turnover regulates Draper-mediated glial engulfment in Drosophila, linking PLCG2 to neurodegenerative disease risk.
bioRxiv · Jun 9, 2026 · PreprintNeuroscience