Author
The Francis Crick InstituteORCID 0000-0002-6800-162XUnclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Benjamin J. O’Callaghan, Daniela Melandri, Darija Šoltić…·Hélène Plun‐Favreau
This study shows that glucose levels in neuronal culture media affect PINK1-dependent mitophagy in human iNeurons, with BrainPhys medium reducing mitophagy compared to N2B27.
Freya Storer, E. A. MacKinnon, Hannah J Lucas-Clarke…·Gaynor Ann Smith
This study shows that PLCγ-dependent phosphoinositide turnover regulates Draper-mediated glial engulfment in Drosophila, linking PLCG2 to neurodegenerative disease risk.
Laura Mahoney‐Sanchez, Hannah J Lucas-Clarke, Alexis Penverne…·Sonia Gandhi
This study shows that the SNCA A53T mutation increases vulnerability to ferroptosis in neurons and microglia, suggesting 15-LO inhibition as a potential therapeutic target for Parkinson's disease.
James R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith…·Sonia Gandhi
The paper identifies microglial activation and alpha-synuclein oligomers as drivers of early neuroinflammation in Parkinson's disease using transcriptomic and aggregate profiling in early-stage brain samples.
Hannah J Lucas-Clarke, Daniel C. Maddison, Leonardo Amadio…·Gaynor Ann Smith
This study identifies Wwox as a protective factor against Alzheimer's disease by modulating metabolic pathways and reducing amyloid pathology in a Drosophila model.
Hannah J Lucas-Clarke, Eirini Messaritaki, Stavros I. Dimitriadis, Claudia Metzler‐Baddeley
This study identifies a structural brain network hub in the right paracentral lobule associated with dementia risk factors in asymptomatic individuals, without affecting other graph theoretical measures.