Sertad1 is elevated and plays a necessary role in synaptic loss, neuron death and cognitive impairment in a model of Alzheimer's disease
Naqiya Ambareen, Kusumika Gharami, Subhas Chandra Biswas
This study identifies Sertad1 as a key mediator of autophagy dysfunction in Alzheimer's disease, showing its role in synaptic loss, neuron death, and cognitive impairment, and demonstrates that its knockdown improves these outcomes.
bioRxiv · Aug 6, 2024 · PreprintNeuroscience