Subhas Chandra Biswas

Exosomal miR-23a release coincides with astrocytic calcineurin activation, protects neurons from apoptosis by regulating NOXA in Parkinson's disease models and is enriched in the plasma of patients with Parkinson's disease

This study identifies exosomal miR-23a release from astrocytes as a neuroprotective mechanism in Parkinson's disease, linked to calcineurin activation and reduced neuronal apoptosis, with elevated levels observed in patient plasma.

A unique serum-free murine cortical astrocyte culture to study endoplasmic reticulum stress in response to amyloid-β

This study develops a serum-free murine astrocyte culture to investigate ER stress and inflammation in response to amyloid-beta, showing enhanced ER stress and inflammatory responses under specific conditions.

Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRB/E2F1 pathway in a model of Parkinson's disease

Sertad1 is elevated and plays a necessary role in synaptic loss, neuron death and cognitive impairment in a model of Alzheimer's disease

This study identifies Sertad1 as a key mediator of autophagy dysfunction in Alzheimer's disease, showing its role in synaptic loss, neuron death, and cognitive impairment, and demonstrates that its knockdown improves these outcomes.

Intercellular adhesion molecule-1 reprograms microglia to improve cognitive functions by inhibiting ERK/STAT3 signalling pathway in a model of Alzheimer's disease

This study shows ICAM-1 reduces microglial inflammation and improves cognitive function in Alzheimer's disease by inhibiting the ERK/STAT3 pathway.

An astrocyte-derived cytokine restores synaptic plasticity in a mouse model of Alzheimer's disease

This study identifies TIMP-1 as a cytokine that restores synaptic plasticity in a mouse model of Alzheimer's disease by protecting neurons and enhancing synaptic function.

Rheb-mTOR Activation Rescues Amyloid Beta-Induced Cognitive Impairment and Memory Function by Restoring miR-146 Activity in Glial Cells

The paper identifies that Rheb-mTOR activation restores miR-146 activity in glial cells, reducing amyloid beta-induced cytokine production and rescuing cognitive impairment in a rat Alzheimer's model.