Author

James R. Downing

St. Jude Children's Research HospitalORCID 0009-0004-4853-7672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Jinghui ZhangiD· 2 shared Aman PateliD· 1 shared Beisi XuiD· 1 shared Chimene A. KesserwaniD· 1 shared Clay McLeodiD· 1 shared Dale J. Hedges· 1 shared Donald Albert YergeauiD· 1 shared Evadnie RampersaudiD· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioinformatics

Jinghui ZhangORCID

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2 papers

Recent·Most cited

Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): A Cloud-based Platform for Curating and Classifying Germline Variants

Michael N. Edmonson, Aman Patel, Dale J. Hedges, Zhaoming Wang, Evadnie Rampersaud, Chimene A. Kesserwan, Xin Zhou, Yanling Liu, Scott Newman, Michael Rusch, Clay McLeod, Mark R. Wilkinson, Stephen V. Rice, Thierry Soussi, J. Paul Taylor, , Jinghui Zhang

PeCanPIE is a cloud-based platform for annotating and classifying germline variants in pediatric cancer, using ACMG guidelines to rank and classify variants from VCF files.

Genome Research · Sep 1, 2019Peer-reviewedBioinformatics

Contribution Of Genetic Variation And Developmental Stage To Methylome Dynamics In Myeloid Differentiation

Xiang 'Anthony' Chen, Yiping Fan, Jinjun Cheng, Beisi Xu, Yong‐Dong Wang, Donald Albert Yergeau, John B. Easton, James R. Downing, Jinghui Zhang

The paper identifies differentially methylated regions in myeloid differentiation, showing genetic and developmental influences on methylome dynamics.

bioRxiv · May 1, 2017 · PreprintGenomics