Yiping Fan

The paper identifies glycerophospholipid biosynthesis upregulation as a mechanism of chemoresistance in SLFN11-loss Ewing sarcoma and shows that inhibiting this pathway enhances DNA-damaging agent efficacy.

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.

This study shows CDK6 promotes oRG expansion and neocortical folding in mice, ferrets, and human cerebral organoids, with its function independent of kinase activity and disrupted by microcephaly-causing mutations.

This study identifies Snip1 as a regulator of neural progenitor cell fates by interacting with PRC2 to control apoptosis, cell division, and neurogenesis in the developing mouse brain.

This study shows YAP/TAZ are essential for maintaining radial glial cell function during brain development, affecting neuronal and ependymal cell numbers and causing hydrocephaly when disrupted.

CovidExpress provides an open-access database and tool for exploring SARS-CoV-2 related gene expression data across tissues and conditions, identifying common regulated genes and a potential FURIN feedback loop.

This study identifies MiDAC as a regulator of neurodevelopmental gene expression by modulating histone acetylation and neurite outgrowth.

The paper identifies differentially methylated regions in myeloid differentiation, showing genetic and developmental influences on methylome dynamics.