Beisi Xu

This study identifies CCL2 as a chemokine that limits osteosarcoma metastasis via NK cell signaling in a mouse model.

The paper shows that active repression by the TEAD-INSM1 complex maintains neural identity during cerebellum development by preventing muscle fate activation.

This study shows that BRD4 recruitment can desilence transcription within repressive chromatin without removing H3K9me3 or HP1, challenging conventional models of chromatin regulation.

This study identifies four resistance mechanisms to sustained auxin-inducible protein degradation in human cells and mice using the AID2 system.

The paper identifies 'pliancy genes' in Muller glia that enable rapid response to retinal stress, injury, and disease, showing species-specific differences in their activation between zebrafish and mammals.

The paper identifies evolutionarily conserved VSX2 enhancer modules in retinal development and shows their functional conservation across species.

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.

The paper introduces ConVERGD, a single-construct intersectional AAV strategy for targeting specific cell populations, and demonstrates its use in targeting NE+ LC neurons expressing Pdyn in rodents.

This study identifies Snip1 as a regulator of neural progenitor cell fates by interacting with PRC2 to control apoptosis, cell division, and neurogenesis in the developing mouse brain.

The paper shows that MiDAC and MLL3/4 complexes antagonistically regulate H4K20ac and gene expression through their interaction and co-localization at enhancer regions.

CovidExpress provides an open-access database and tool for exploring SARS-CoV-2 related gene expression data across tissues and conditions, identifying common regulated genes and a potential FURIN feedback loop.

MethylationToActivity infers promoter activity from DNA methylation data in tumors, showing high accuracy across multiple cancer types.

The paper identifies a human accelerated region in Chromosome 14q12 that enhances forebrain expansion through increased enhancer activity in transgenic mice and organoids.

The paper studies the chromatin structure of rod photoreceptors in mice using Hi-C and machine learning to identify regulatory elements involved in retinal development.

The paper identifies differentially methylated regions in myeloid differentiation, showing genetic and developmental influences on methylome dynamics.