Lin Li

INSM1 Regulates Neuroendocrine Plasticity and Tumor Progression in Prostate Cancer

This study identifies INSM1 as a key regulator of neuroendocrine plasticity and tumor progression in prostate cancer, showing its role in lineage programs and identifying HHT as a potential therapeutic agent.

A MYC Family Switch: L-MYC Drives and Maintains Neuroendocrine Lineage Programs in Prostate Cancer

This study identifies MYCL as a key driver of neuroendocrine lineage programs in prostate cancer by showing its upregulation in NEPC and its role in suppressing AR signaling and inducing neuroendocrine reprogramming.

Androgen Deprivation-Induced TET2 Activation Fuels Prostate Cancer Progression via Epigenetic Priming and Slow-Cycling Cancer Cells

This study identifies TET2 activation in slow-cycling cells as a driver of prostate cancer progression through epigenetic changes and shows targeting TET2 suppresses tumor growth.

Wnt/Beta-Catenin Signaling Is Active in Neuroendocrine Prostate Cancer

This study investigates Wnt/beta-Catenin signaling in neuroendocrine prostate cancer, finding elevated pathway activity and potential therapeutic targeting.

Systematic Multi-Omics Investigation of Androgen Receptor Driven Gene Expression and Epigenetics changes in Prostate Cancer

This study investigates AR-driven gene expression and epigenetic changes in prostate cancer using multi-omics data from LNCaP cells, identifying gene expression shifts and AR binding patterns under androgen deprivation therapy.