Author

Su Deng

Yale Cancer CenterORCID 0000-0002-0835-2452Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Ping MuiD· 4 shared Isaac Yi KimiD· 3 shared Yuyin JiangiD· 3 shared Siyuan ChengiD· 2 shared Jiaying Qian· 1 shared Lin LiiD· 1 shared Longjun Li· 1 shared Melanie Fraidenburg· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCancer Biology

Ping MuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ATHENA: A deep learning-based AI for functional prediction of genomic mutations and synergistic vulnerabilities in prostate cancer

Siyuan Cheng, Xiao Jin, Jiaying Qian, Yuyin Jiang, Isaac Yi Kim, Su Deng, Ping Mu

ATHENA predicts functional genomic mutations and synergistic vulnerabilities in prostate cancer using deep learning, identifying driver events and therapeutic targets through integration with variant discovery pipelines.

bioRxiv · Nov 26, 2025 · PreprintCancer Biology

Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Longjun Li, Melanie Fraidenburg, Isaac Yi Kim, Su Deng, Ping Mu

This study identifies Notch signaling as a driver of lineage plasticity and therapeutic resistance in enzalutamide-resistant prostate cancer and shows its inhibition reverses resistance in vitro.

bioRxiv · May 26, 2025 · PreprintCancer Biology

Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity

Yuyin Jiang, Siyuan Cheng, Isaac Yi Kim, Su Deng, Ping Mu

The paper identifies ectopic RUNX1T1 expression as a pan-cancer marker associated with lineage plasticity across multiple cancer types.

bioRxiv · Apr 18, 2025 · PreprintCancer Biology

Androgen Deprivation-Induced TET2 Activation Fuels Prostate Cancer Progression via Epigenetic Priming and Slow-Cycling Cancer Cells

Lin Li, Siyuan Cheng, Yaru Xu, Su Deng, Ping Mu, Xiuping Yu

This study identifies TET2 activation in slow-cycling cells as a driver of prostate cancer progression through epigenetic changes and shows targeting TET2 suppresses tumor growth.

bioRxiv · Mar 26, 2025 · PreprintCancer Biology