Chemical Rescue Serves as a Predictive Proxy for Glycosynthase Activity on Glycosidic Bonds via a Shared Glycosyl Oxocarbenium Transition State
M. Suresh Kumar, Chandra Kanth Bandi, Sri Vidya Vyjayanthi Tallavajhula, Tucker Burgin, Srinivas V. S. Chakravartula, Shishir P. S. Chundawat
The paper demonstrates that chemical rescue is a predictive proxy for glycosynthase activity, validated through correlation with enzymatic activity and transition state analysis.
bioRxiv · Jul 31, 2026 · PreprintBiochemistry