Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma
Aldo Prawira, Hang Xu, Wei Qiang Leow, Masayuki Otsuka, Ziyao Chen, Mohammad Rahbari, Sharifah Nur Hazirah, Martin Wasser, Alexander Yaw Fui Chung, Brian K. P. Goh, Pierce K. H. Chow, Salvatore Albani, Joycelyn Jie Xin Lee, Tony K.H. Lim, Weiwei Zhai, , Valerie Chew
This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.
bioRxiv · May 9, 2024 · PreprintImmunology