Pierce K. H. Chow

RankMap improves cell type annotation in spatial and single-cell transcriptomics by using rank-based representations and multinomial regression, achieving competitive accuracy and faster runtime.

SpNeigh analyzes spatial transcriptomics data to detect neighborhood effects and differential expression, revealing tissue interface populations and spatial gene patterns in mouse brain, human breast cancer, and liver.

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

This study identifies Esrra's role in regulating Rplp1-mediated translation of lysosomal and autophagy proteins during NASH, showing that alternate day fasting can reverse these effects.

The paper uses scRNA-seq to identify TROP2+ liver progenitor cells co-expressing ACE2 and TMPRSS2, suggesting they may be targets for SARS-CoV-2 infection and contribute to COVID-19-associated liver dysfunction.