Brian K. P. Goh

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

The paper uses scRNA-seq to identify TROP2+ liver progenitor cells co-expressing ACE2 and TMPRSS2, suggesting they may be targets for SARS-CoV-2 infection and contribute to COVID-19-associated liver dysfunction.