Weiwei Zhai

This study compares the genomic evolution of sporadic and hereditary colorectal precancers using single-crypt whole-genome sequencing, revealing distinct mutation patterns and evolutionary trajectories.

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

PRECAST integrates spatial transcriptomics data from multiple sources, improving cell and domain detection through probabilistic embedding, clustering, and alignment.

The paper introduces PhyloVelo, a method that uses monotonically expressed genes to reconstruct cell fate transitions, outperforming existing approaches in embryo development and tumor evolution analysis.

The study analyzes genetic diversity in multiple hepatocellular carcinomas, finding that low-frequency mutations pre-exist and contribute to drug resistance, presenting challenges and opportunities for cancer therapeutics.