Hepatitis B virus HBx protein masks epigenetic reader Spindlin1 via an inter-molecular zinc finger to subvert transcriptional control
Alexis Clavier, Toshinobu Shida, Maxim A. Droemer, Santiago Gómez-Evain, Franziska von Hammerstein, Julian Holzinger, Mila M. Leuthold, Céline Douat, Anne K. Schütz
This study identifies how HBx protein interacts with Spindlin1 via a zinc finger to disrupt epigenetic control and promote viral DNA transcription.
Nature Communications · May 25, 2026Peer-reviewedBiophysics