Author

M.M. Leuthold

Heidelberg UniversityORCID 0000-0001-7698-2360Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexis ClavieriD· 1 shared Anne K. SchütziD· 1 shared Byron MartinaiD· 1 shared Céline DouatiD· 1 shared Christian D. P. KleiniD· 1 shared Franziska von Hammerstein· 1 shared Johannes LangiD· 1 shared Julian HolzingeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Alexis ClavierORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedMay 25, 2026

Hepatitis B virus HBx protein masks epigenetic reader Spindlin1 via an inter-molecular zinc finger to subvert transcriptional control

Alexis Clavier, Toshinobu Shida, Maxim A. Droemer…·Anne K. Schütz

This study identifies how HBx protein interacts with Spindlin1 via a zinc finger to disrupt epigenetic control and promote viral DNA transcription.

DOI 10.1038/s41467-026-72986-5

humanprotein structure

𝕏 PostBluesky

Pharmacology & ToxicologyAntiviral ResearchPeer-reviewedDec 5, 2024

Antiviral Drug Discovery with an Optimized Biochemical Dengue Protease Assay: Improved Predictive Power for Antiviral Efficacy

Johannes Lang, Sudip Kumar Dutta, M.M. Leuthold…·Christian D. P. Klein

This study improves the predictive power of a biochemical dengue protease assay for antiviral efficacy by optimizing conditions and evaluating phenylglycine-based inhibitors.

9 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky