Generalized Chargaff symmetry in codon usage across the tree of life
Virginia Iannibelli, Isabella Caranzano, Giovanni Birolo, Cesare Rollo, Francesco Codicè, Guido Barducci, Cristian Taccioli, Luca Pagani, Piero Fariselli
The paper quantifies reverse-complement symmetry in codon usage across taxa and shows it is not fully explained by compositional constraints.
bioRxiv · Jul 9, 2026 · PreprintEvolutionary Biology