Guido Barducci

The paper develops a method combining evolutionary and protein language model representations to predict protein stability changes with thermodynamic consistency, improving accuracy and physical consistency.

The paper introduces ProbJanusDDG to prioritize mutations for experimental follow-up by using conformal prediction intervals to assess uncertainty in predicted stability changes.

The paper quantifies reverse-complement symmetry in codon usage across taxa and shows it is not fully explained by compositional constraints.