Luca Pagani

The paper develops a multi-task neural network to predict blood metabolite profiles by separating covariate, genetic, and joint effects, finding nonlinear covariate modeling improves prediction.

The paper quantifies reverse-complement symmetry in codon usage across taxa and shows it is not fully explained by compositional constraints.

The paper examines the effects of Neanderthal introgressed alleles on brain morphology and neuropsychiatric traits using UK Biobank data, identifying associations with specific brain regions and mental health outcomes.

The paper uses UK Biobank data to infer Neanderthal population history and introgression patterns, finding divergence times, effective population sizes, and regions of selection.

This study analyzes ancient DNA to reveal the 2500-year evolutionary history of human betaherpesviruses 6A and 6B, showing established diversity by the 14th century and ancient integration into the human genome.

The paper analyzes ancient genomes from Roca Vecchia to determine genetic contributions from Minoans and local populations during the Bronze Age.

The paper shows that migration behavior in Estonia increases spatial genetic differentiation at trait-associated loci, with educational attainment PGS driving inter-regional differences.

The paper estimates genetic assortative mating using haplotype reconstruction in large biobank cohorts, revealing recent trends in mate choice and its genetic impact.

This study combines genetic data and mythological motifs to show that population movements and cultural diffusion shaped the distribution of myths globally, with evidence dating back to 38,000 years ago.

The paper identifies 56 recent functional variants in modern humans, 24 linked to brain functions and skull morphology, which did not introgress into Neanderthals.

This study investigates the association between ancestral genetic components and complex traits in European biobanks, finding that these components contribute to trait variation and act as confounders.

ASAP uses PCA and NNLS to reliably estimate ancestry in admixed individuals, even with high missing data, and performs faster than existing tools.

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.

The paper analyzes genome-wide SNP data from Southern Italy and neighboring regions to assess historical contacts and genetic affinities across the Adriatic Sea.

The paper analyzes ancient DNA from Iron Age Apulian sites to explore the genetic origins of the Daunians and their place in the Pan-Mediterranean genetic landscape.

This paper uses a deep learning approach to analyze whole-genome sequences and supports the back to Africa model over other hypotheses about human migration.

This study connects genetic ancestry from three ancient populations to complex traits in Estonian Biobank samples, finding ancestry-specific contributions to traits like BMI and blood cholesterol.

The paper identifies shared post-admixture adaptation patterns in the Americas by analyzing genomic data from 6,000 admixed individuals, highlighting regions associated with immune response and disease traits.

The paper presents genomic data from a Late Epigravettian individual in Italy dated to 16,980-16,510 cal BP, showing genetic replacement associated with the emergence of Late Epigravettian culture, pushing back the spread of a Balkan/Anatolian genetic component by 3,000 years.

The paper analyzes genomic data from Indigenous groups in Panama to reveal pre-Hispanic demographic changes and the genetic structure of the Isthmo-Colombian area.

This study uses generative models to create artificial human genomes that can improve genetic research without compromising privacy.

This study analyzes the genetic impact of European colonization on the Americas using genome-wide data from 12,000 individuals, revealing complex contributions from European, African, and other sources.

The paper analyzes genomic heterogeneity within European population isolates and finds that inter-individual variation is comparable to non-isolated populations, with some isolates showing higher levels due to recent introgression.

The paper analyzes the genetic structure of modern-day Italians to reveal ancient and archaic ancestries shaping Southern European populations and Neanderthal DNA distribution.

This paper shows that DNA sequence patterns arise from physical constraints of dsDNA and maximum entropy, not evolutionary pressure.

The paper estimates admixture dates and identifies source populations for genetic components in Indian Austroasiatic speakers using genome-wide data.

This study identifies human-specific non-LTR retrotransposon insertions and shows their association with gene expression changes and phenotypic evolution in humans.

The paper identifies genomic regions with high or low population differentiation using 911 whole-genome sequences, finding that highly differentiated sites are enriched for positive selection.