The paper compares outcomes of X-poisoning and X-shredding in malaria mosquitoes by timing Cas9 expression during spermatogenesis, finding that timing determines distortion type.

bioRxiv · Mar 31, 2026 · PreprintGenetics

An OpIE2-DsRed marker disrupts female blood-feeding and shortens lifespan in the malaria vector Anopheles gambiae.

Arad Sarig, Evyatar Sar-Shalom, Ebrima SM Kolley, Elad Shmuel Yonah, Lee Benjamin Lamdan, A. Lewin, Tamir Partosh, Gur Pines, Jonathan Daniel Bohbot, Philippos Aris Papathanos

This study identifies a fluorescent marker that disrupts female blood-feeding and shortens lifespan in Anopheles gambiae, highlighting the importance of validating transgenic components.

Genetics · Dec 31, 2025Peer-reviewedGenetics

Targeting mosquito X-chromosomes reveals complex transmission dynamics of sex ratio distorting gene drives

Daniella An Haber, Yael Arien, Lee Benjamin Lamdan, Yehonathan Alcalay, Chen Zecharia, Flávia Krsticevic, Elad Shmuel Yonah, Rotem Daniel Avraham, Elzbieta Krzywińska, Jaroslaw Krzywinski, Éric Marois, Nikolai Windbichler, Philippos Aris Papathanos

This study investigates X-poisoning gene drives in mosquitoes, finding that sex distortion is mainly due to loss of X-bearing sperm rather than postzygotic lethality.

Nature Communications · Jun 11, 2024Peer-reviewedSynthetic Biology