Quantitative Membrane Binding Assays Reveal an Inhibitory Role for the BRAF-Specific Region in CRD and Lipid Interaction
Vasili Revazishvili, Alexia Morales, Bryn Baxter, Julian Grim, Ani Chakhrakia, Andres Jimenez Salinas, Angelica M. Riestra, Young Kwang Lee
The paper identifies the BRAF-specific region (BSR) as an inhibitory module that reduces CRD lipid binding, with implications for BRAF membrane dynamics and therapeutic targeting.
bioRxiv · Aug 3, 2025 · PreprintBiochemistry