Young Kwang Lee

The paper shows how RAF's RBD and CRD domains work together to regulate its membrane binding through lateral rebinding, enhancing signaling specificity in RAS nanoclusters.

The paper identifies the BRAF-specific region (BSR) as an inhibitory module that reduces CRD lipid binding, with implications for BRAF membrane dynamics and therapeutic targeting.

The paper shows that the regulatory segment of CaMKII can break the oligomeric hub into smaller assemblies through binding and structural destabilization.