Author

Wyatt A. Curtis

École Polytechnique Fédérale de LausanneORCID 0009-0004-9452-5285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Marcel DrabbelsiD· 3 shared Ulrich Joseph LorenziD· 3 shared Barrass SViD· 2 shared Jakub Wenz· 2 shared Constantin R. KrügeriD· 1 shared Harry M. WilliamsiD· 1 shared J HrubyiD· 1 shared Laurence T. SeeleyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

Marcel DrabbelsORCID

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3 papers

Recent·Most cited

Cryo-EM Sample Preparation with Soft-Landing and Laser Flash Melting

Barrass SV, Tim K. Esser, Nathan J. Mowry, Lukas Eriksson, J Hruby, Laurence T. Seeley, Wyatt A. Curtis, Lindsay A. Baker, Marcel Drabbels, Stephan Rauschenbach, Ulrich Joseph Lorenz

This paper demonstrates a method to rehydrate proteins after soft-landing for cryo-EM by flash melting, enabling native configurations and improving sample preparation.

Nature Communications · Sep 15, 2026Peer-reviewedBiophysics

Ultrathin Liquid Cells for Microsecond Time-Resolved Cryo-EM

Wyatt A. Curtis, Jakub Wenz, Constantin R. Krüger, Barrass SV, Marcel Drabbels, Ulrich Joseph Lorenz

This paper introduces ultrathin liquid cells for microsecond time-resolved cryo-EM, enabling longer observation windows and improved resolution for studying protein dynamics.

Nature Communications · Jan 22, 2026Peer-reviewedBiochemistry

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification

Harry M. Williams, Wyatt A. Curtis, Michal Haubner, Jakub Wenz, Marcel Drabbels, Ulrich Joseph Lorenz

This paper introduces a method to overcome preferred orientation in cryo-EM by using ultrasonic excitation during vitrification, improving data acquisition efficiency.

bioRxiv · Sep 14, 2025 · PreprintBiophysics