Guanglin Chen

Conformational Dynamics of the Nuclear Pore Complex: Insights from Elastic Network Models and Coarse-Grained Simulations

This study uses elastic network models and molecular dynamics simulations to analyze the conformational dynamics of the nuclear pore complex, revealing mechanisms of its two-state transition and FG repeat behavior.

De novo identification of protein domains in cryo-electron tomography maps from AlphaFold2 models

DomainSeeker identifies protein domains in cryo-ET maps using AlphaFold2 structures and Bayesian inference, improving accuracy and resolution robustness.

IDRWalker: A Random Walk based Modeling Tool for Disordered Regions in Proteins

IDRWalker models intrinsically disordered regions in large protein complexes using random walks, completing nuclear pore complex modeling in minutes.