Yun Zhu

This study reveals the subnanometer architecture of basal bodies in mammalian cells, identifies new components, and proposes a mechanism for central pair microtubule nucleation during ciliogenesis.

cryoAgent improves cryo-EM image processing by enabling autonomous, adaptive workflows that enhance reconstruction quality and identify new structural states.

The paper identifies TRiC/CCT as a chaperonin in mammalian sperm flagella that folds locally translated proteins, supporting flagellar function and fertility.

This study reveals that Arpin homodimerization enhances inhibition of Arp2/3 complex-mediated actin polymerization, suppressing cancer cell migration and metastasis.

This study shows that CFAP77 is essential for connecting axonemal A and B tubules in mammalian sperm, as its loss disrupts the CFAP77-CCDC105-TEX43 complex and impairs sperm motility.

BTFBS predicts bacterial transcription factor binding using deep learning, achieving high accuracy on test datasets.

This study investigates whether pulsed-electron imaging in ultrafast cryo-EM mitigates radiation damage, finding no significant mitigation effect despite varying experimental conditions.

This study identifies ANKRD5 as a critical component of the N-DRC in sperm axonemes, showing its role in maintaining structural integrity and motility, with implications for male fertility.

DomainSeeker identifies protein domains in cryo-ET maps using AlphaFold2 structures and Bayesian inference, improving accuracy and resolution robustness.

The paper solves the in-cell structure of mouse sperm central apparatus at sub-nanometer resolution and identifies proteins critical for its asymmetric assembly.

DeepETPicker improves 3D particle picking in cryo-electron tomography with weakly supervised deep learning, achieving higher accuracy and speed than existing methods.

The paper determines the 8 Å cryo-EM structure of the Xenopus laevis nuclear pore complex nuclear ring using AlphaFold2 to build a pseudoatomic model.

The paper determines the architecture of the nuclear ring in Xenopus laevis NPC using cryo-EM, homology modeling, and cell experiments, identifying key proteins and their roles in NPC assembly.

The paper solves the 8 Å cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring using AlphaFold2, revealing detailed structural features of key components.