Zhiyong Zhang

This study uses elastic network models and molecular dynamics simulations to analyze the conformational dynamics of the nuclear pore complex, revealing mechanisms of its two-state transition and FG repeat behavior.

DomainSeeker identifies protein domains in cryo-ET maps using AlphaFold2 structures and Bayesian inference, improving accuracy and resolution robustness.

The paper solves the in-cell structure of mouse sperm central apparatus at sub-nanometer resolution and identifies proteins critical for its asymmetric assembly.

IDRWalker models intrinsically disordered regions in large protein complexes using random walks, completing nuclear pore complex modeling in minutes.