Author

Achim A. Jungbluth

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-8949-2333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Afşar BarlasiD· 1 shared Aleksandar ObradovićiD· 1 shared Andrea M. GazzoiD· 1 shared Anton Mikhailovich SafonoviD· 1 shared Antonio MarraiD· 1 shared Anuradha GopalaniD· 1 shared Avantika GuptaiD· 1 shared Bojana StefanovskaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Afşar BarlasORCID

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2 papers

Recent·Most cited

APOBEC3 mutagenesis drives therapy resistance in breast cancer

Avantika Gupta, Andrea M. Gazzo, Pier Selenica, Anton Mikhailovich Safonov, Fresia G. Pareja, Edaise M. da Silva, David N. Brown, Hong Shao, Yingjie Zhu, Juber Patel, Juan Blanco-Heredia, Bojana Stefanovska, Michael A. Carpenter, Yanjun Chen, Isabella Vegas, , Sarat Chandarlapaty

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

Nature Genetics · May 16, 2025Peer-reviewedCancer Biology

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

Samir Zaidi, Jooyoung Park, Joseph Minhow Chan, Martine P. Roudier, Jimmy L. Zhao, Anuradha Gopalan, Kristine M. Wadosky, Radhika A. Patel, Erolcan Sayar, Wouter R. Karthaus, D. Henry Kates, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Linas Mažutis, , Charles L. Sawyers

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Proceedings of the National Academy of Sciences · Jul 5, 2024Peer-reviewedCancer Biology