Zoey J Tolboom

This study identifies PI3K signaling as a key driver of inflammatory tumor-macrophage communication in mesenchymal glioblastoma, showing its role in vascular remodeling and immune evasion.

This study investigates how CSF1R inhibition during cranial radiotherapy affects the brain's immune environment and glial dynamics, showing sustained microglial loss and monocyte replacement.

This study shows that high-dose CSF1R inhibitors pexidartinib and sotuletinib rapidly deplete microglia despite limited brain penetration, with significant off-target effects on other immune and tissue cells.