Caroline L. Van Heijningen

This study investigates how CSF1R inhibition during cranial radiotherapy affects the brain's immune environment and glial dynamics, showing sustained microglial loss and monocyte replacement.

This study shows that high-dose CSF1R inhibitors pexidartinib and sotuletinib rapidly deplete microglia despite limited brain penetration, with significant off-target effects on other immune and tissue cells.