Author

Kevin X. Chen

University of California, San FranciscoORCID 0009-0005-3156-6394Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Robert H. BlellochiD· 2 shared Ryan M. BoileauiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersMolecular Biology

Robert H. BlellochORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 16, 2026

KMT2C and KMT2D amplify GRHL2-driven enhancer activation

Ryan M. Boileau, Kevin X. Chen, Robert H. Blelloch

This study develops an inducible system to study enhancer activation in ESCs and shows that KMT2C/D amplify GRHL2-driven enhancer activation.

DOI 10.64898/2026.03.10.710694

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 24, 2022

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during ESC differentiation

Ryan M. Boileau, Kevin X. Chen, Robert H. Blelloch

This study shows that MLL3/4 are essential for dynamic enhancer histone modifications but not for stable ones, and their loss does not impair transcriptional activation of nearby genes.

3 citations

𝕏 PostBluesky