Ryan M. Boileau

This study develops an inducible system to study enhancer activation in ESCs and shows that KMT2C/D amplify GRHL2-driven enhancer activation.

TurboPRANCE enables large-scale, multi-objective continuous evolution by integrating robotic systems with phage-assisted evolution, generating high-resolution evolutionary data across diverse selection regimes.

This study shows that miR-290 and miR-302 clusters are essential for reprogramming fibroblasts to iPSCs, but individually are not required, while their combined loss blocks the process.

This study shows that cohesin is not always necessary for enhancer function, as some enhancers can act independently through synergy or insulators.

The paper identifies MLL3/MLL4 enzymatic activity as a regulator of DNA replication timing through H3K4me1 modification, showing its role in chromatin structure and replication dynamics during differentiation.

This study shows that MLL3/4 are essential for dynamic enhancer histone modifications but not for stable ones, and their loss does not impair transcriptional activation of nearby genes.