Adrian Idrizi

The paper analyzes DNA methylation stochasticity in AML subtypes, identifying high-entropy subtypes and linking methylation entropy to transcriptional variability and leukemogenesis.

The paper investigates DNA methylation changes during pancreatic acinar-ductal metaplasia (ADM) and their persistence without Kras mutation, linking epigenetic memory to signaling pathway alterations and cancer cell plasticity.

The paper uses mouse models to study diet-induced metabolic syndrome, identifies strain-specific transcriptional and epigenomic changes, and tests genotype-targeted pharmacological interventions.

The paper identifies brain region-specific variably methylated regions (VMRs) enriched for schizophrenia heritability using DNA methylation data from neuronal nuclei across multiple brain regions.

The paper identifies brain region-specific DNA methylation and chromatin accessibility differences and links them to heritability of neuropsychiatric disorders.