Cancer BiologyGenome MedicinePeer-reviewed
Early NOTCH1 mutation is positively selected but epistatically suppresses evolution of later esophageal squamous-cell carcinoma drivers
Kira A. Glasmacher, Jeffrey D. Mandell, Mia Jackson…·Jeffrey P. Townsend
The paper shows early NOTCH1 mutations are selected in normal tissue but suppress later cancer driver mutations through epistasis, highlighting stage-specific mutation effects in esophageal cancer.
5 citations