Author

Madelyn Frazier

Howard Hughes Medical InstituteORCID 0009-0005-5694-024XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Christine JacobsiD· 1 shared Isaac A. PaddyiD· 1 shared Joshua W. McCauslandiD· 1 shared Laura M. K. DassamaiD· 1 shared Mekedlawit T. SetegneiD· 1 shared O. Eidam· 1 shared Poulami ChatterjeeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Christine JacobsORCID

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1 paper

Recent·Most cited

A cofactor-promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Isaac A. Paddy, Joshua W. McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit T. Setegne, O. Eidam, Christine Jacobs, Laura M. K. Dassama

This study identifies HMGR as a critical enzyme in B. burgdorferi's mevalonate pathway, revealing its cofactor promiscuity and evolutionary significance.

Protein Science · Aug 19, 2026Peer-reviewedBiochemistry