Author

Isaac A. Paddy

Stanford MedicineORCID 0000-0002-6090-2191Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Christine JacobsiD· 2 shared Joshua W. McCauslandiD· 2 shared Laura M. K. DassamaiD· 2 shared Poulami ChatterjeeiD· 2 shared Alysha K. LeeiD· 1 shared Hyejin Esther ShiniD· 1 shared Madelyn FrazieriD· 1 shared Mekedlawit T. SetegneiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

Christine JacobsORCID

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Author profile →

2 papers

Recent·Most cited

A cofactor-promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Isaac A. Paddy, Joshua W. McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit T. Setegne, O. Eidam, Christine Jacobs, Laura M. K. Dassama

This study identifies HMGR as a critical enzyme in B. burgdorferi's mevalonate pathway, revealing its cofactor promiscuity and evolutionary significance.

Protein Science · Aug 19, 2026Peer-reviewedBiochemistry

A lipid compendium of a metabolically compromised bacterium provides insights into lipid acquisition, biosynthesis, and metabolism

Poulami Chatterjee, Hyejin Esther Shin, Miles I. Tuncel, Isaac A. Paddy, Alysha K. Lee, Joshua W. McCausland, Paula V. Welander, Christine Jacobs, Laura M. K. Dassama

This study identifies a complex lipid profile in Borrelia burgdorferi, revealing its reliance on environmental lipids and its ability to synthesize eukaryotic-like lipids.

bioRxiv · May 23, 2026 · PreprintBiochemistry