Joshua W. McCausland

This study identifies HMGR as a critical enzyme in B. burgdorferi's mevalonate pathway, revealing its cofactor promiscuity and evolutionary significance.

This study identifies a complex lipid profile in Borrelia burgdorferi, revealing its reliance on environmental lipids and its ability to synthesize eukaryotic-like lipids.

This study identifies PAPI (encoded by pcnB) as essential for maintaining virulence and AMR plasmid copy number, stability, and bacterial virulence in Yersinia and Shigella.

This paper shows that Borrelia burgdorferi loses genetic elements and proliferative ability in lab cultures during starvation but maintains these traits in tick vectors.

This study identifies bacterial enzymes that modify peptidoglycan fragments from Borrelia burgdorferi, showing they are poor immune stimulators and that host enzymes like PGLYRP2 are less active in joint fluids, contributing to persistent arthritis.

This study shows that the CRY2/CIB1 system can be used to precisely control protein localization in E. coli, enabling manipulation of cellular functions like cytokinesis.