Wendy S. Woods

This study uses CRISPR base editing to create HTT protein isoforms resistant to caspase-6 cleavage, reducing toxicity and neurodegeneration in a rodent HD model.

SPLICER improves exon skipping by editing both splice acceptor and donor sites, reducing aberrant splicing and enabling therapeutic applications in Alzheimer's disease.

This study identifies epigenomic and sequence features that influence prime editing efficiency and provides guidelines for optimizing prime editor designs.

This study uses yeast to investigate how DNA methylation is regulated by DNMT3 family members and identifies sequence preferences and spatial patterns of methylation.