Lachlan Gilchrist

The paper identifies novel cross-trait associations using polytranscriptomic scores in Parkinson's disease and improves prediction models with multi-PTS integration.

This study uses Mendelian randomisation to identify causal metabolome-wide effects on psychiatric and neurodegenerative disorders, finding 85 significant associations and shared genetic variants.

This study uses polygenic and transcriptional risk scores to analyze psychiatric and cognitive symptoms in Parkinson's disease, finding distinct associations between genetic and transcriptional risks and symptom progression.

This study uses GWAS summary statistics to identify shared genetic loci across neuropsychiatric diseases and finds HLA region associations with potential shared causal variants.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.